In 1988 I purchased a used F15o with 75k miles on it. Drove it for 6 years and sold it with 275k miles on it. Still running great, and clean. No leaks, not problems.
In 2003 I purchased my second F150, a 2001 that had 50k miles already on it. I am still driving this truck today, and it just rolled 225k. I take it to Mexico, camping with my kids, and drive it daily for work. It still runs great, shifts like a champ, and the interior has held up like a new truck. Hard to believe that I have driven over 500k miles in a ford F150 without one major break down.