My 2001 F-150 longbed with the Triton engine just crossed the 375,000 mile threshold. Other than oil changes every 9,000 miles and the requisite brake and tire replacements and infrequent tune-ups, I’ve had almost no issues. Starter coil went out at 250k, ball joints replaced at 350k, and last month had to have a leaky rear right axle replaced. Other than that, it still drives as well as it did 8 years ago! Looking forward to continued consistent reliability.